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3 Conversion TO Candesartan (per Regional Therapeutic Interchange) eprosartan 600 mg, irbesartan 150 mg, losartan 50 mg, olmesartan 20 mg, telmisartan 40 mg, valsartan 80 mg are equivalent to candesartan 8 mg. www.e-therapeutics.ca. 1 Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Bloc ker vs Diuretic. Intractable cough or angioedema on an Angiotensin Converting Enzyme Inhibitor (ACE-I) and Failure on optimal doses or intolerance to all the fully covered (reference) drugs. Although these medication classes work in a similar fashion, ARBs do not inhibit kinase II which is thought to be responsible for the cough. Available at 1 formulary drug 2 automaticaly interchanged to candesartan at an equivalent dose given once daily. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Angiotensin receptor blockers (ARB), like losartan (Cozaar), are less likely to cause this dry cough. ACE INHIBITOR COMPARISON CHART* Enalapril ƗLisinopril Benazepril Captopril Fosinopril Quinapril Ramipril Prodrug Yes No Yes No Yes Yes Yes Active Moeity Enalaprilat Lisinopril Benazeprilat Captopril Fosinoprilat Quinaprilat Ramiprilat Reference 539 540 1. Ɨ Product in stock for Blessings International. ACE-Inhibitors 20-40 mg daily 7.5-30 mg daily in 1-2 divided doses 4-16 mg daily in 1-2 divided doses 20-80 mg daily in 1-2 divided doses 10 mg daily 7.5 mg daily 4 mg daily 10-20 mg daily Lisinopril (Prinivil, Zestril) Moexipril (Univasc) Perindopril (Aceon) Quinapril (Accupril) Dosing of ACE-Inhibitors and ARBs EPANED is an angiotensin-converting enzyme inhibitor indicated for: •treatment of hypertension in adults and children older than one month, to lower blood pressure. ACE Inhibitors [CPhA monograph] Available from . CONVERSION TABLES TABLE 2. 537 Supplemental Table 1. Conversion FROM Candesartan Use clinical judgement; … 2011 Oct; cited 2016 Apr 25]. All ARBs; ACE inhibitors - see combining ARBs and ACE inhibitors; Aliskiren (Tekturna®) - Aliskiren should not be prescribed with ARBs in patients with diabetes or decreased kidney function (GFR<60ml/min) Lithium - ARBs can increase lithium levels. Angiotensin converting enzyme (ACE) inhibitor antihypertensive dose comparison. Dose Equivalents (mg/day) Doxazosin and terazosin are therapeutically equivalent for the treatment of hypertension and benign ( 1.1) ASL-02 Automatic Substitution List - ACE Inhibitors and ARBs €In order to simplify drug therapy, orders for one medication may be automatically substituted (also known as therapeutic interchange) to a different medication that is considered therapeutically equivalent. Comparison of Angiotensin Converting Enzyme (ACE) Inhibitors. ACE to ARB Conversion Table Angiotensin Receptor Blocker (ARB) Dose Conversion Drugs Low Dose Medium Dose High Dose losartan (Cozaar) 125. Pharmacist's Letter/Prescriber's Letter 2009;25(8):250801.541 542 543 544 545 Also available in paper copy from the publisher. Approximate daily equivalent doses of ARBs 1-3 (Micromedex Healthcare series, Vol 119) 2: Ramipril 5-10mg daily is considered equivalent to Captopril 50mg bd for the treatment of hypertension (Micromedex Healthcare series, Vol 119) Monitoring requirements when switching ACE-inhibitors The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Switching from lisinopril to losartan may help reduce the likelihood of developing a dry cough. 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